Journal of Pain and Symptom Management
Volume 36, Issue 3 , Pages 228-234 , September 2008

Palliative Sedation in a Specialized Unit for Acute Palliative Care in a Cancer Hospital: Comparing Patients Dying With and Without Palliative Sedation

  • Judith A.C. Rietjens, PhD

      Affiliations

    • Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
    • Corresponding Author InformationAddress correspondence to: Judith A.C. Rietjens, PhD, Department of Public Health, Erasmus MC, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
    • ,
  • Lia van Zuylen, MD, PhD

      Affiliations

    • Department of Medical Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    • ,
  • Hetty van Veluw, RN, CNS

      Affiliations

    • Department of Medical Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    • ,
  • Lidemarie van der Wijk, MSc

      Affiliations

    • Department of Medical Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    • ,
  • Agnes van der Heide, MD, PhD

      Affiliations

    • Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
    • ,
  • Carin C.D. van der Rijt, MD, PhD

      Affiliations

    • Department of Medical Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands

,Accepted 1 November 2007.

References 

  1. Vainio A, Auvinen A. Prevalence of symptoms among patients with advanced cancer: an international collaborative study. Symptom Prevalence Group. J Pain Symptom Manage. 1996;12:3–10
  2. Klinkenberg M, Willems DL, van der Wal G, Deeg DJ. Symptom burden in the last week of life. J Pain Symptom Manage. 2004;27:5–13
  3. de Graeff A, Dean M. Palliative sedation therapy in the last weeks of life: a literature review and recommendations for standards. J Palliat Med. 2007;10:67–85
  4. Goncalves JA. Sedation and expertise in palliative care. J Clin Oncol. 2006;24:e44–e45
  5. Billings JA, Block SD. Slow euthanasia. J Palliat Care. 1996;12:21–30
  6. Quill TE, Byock IR. Responding to intractable terminal suffering: the role of terminal sedation and voluntary refusal of food and fluids. ACP-ASIM End-of-Life Care Consensus Panel. American College of Physicians-American Society of Internal Medicine. Ann Intern Med. 2000;132:408–414
  7. Quill TE, Lo B, Brock DW. Palliative options of last resort: a comparison of voluntarily stopping eating and drinking, terminal sedation, physician-assisted suicide, and voluntary active euthanasia. JAMA. 1997;278:2099–2104
  8. Rietjens JA, van der Heide A, Vrakking AM, et al. Physician reports of terminal sedation without hydration or nutrition for patients nearing death in the Netherlands. Ann Intern Med. 2004;141:178–185
  9. Miccinesi G, Rietjens JA, Deliens L, et al. Continuous deep sedation: physicians' experiences in six European countries. J Pain Symptom Manage. 2006;31:122–129
  10. Muller-Busch HC, Andres I, Jehser T. Sedation in palliative care—a critical analysis of 7 years experience. BMC Palliat Care. 2003;2:2
  11. Sykes N, Thorns A. Sedative use in the last week of life and the implications for end-of-life decision making. Arch Intern Med. 2003;163:341–344
  12. Fainsinger RL, Waller A, Bercovici M, et al. A multicentre international study of sedation for uncontrolled symptoms in terminally ill patients. Palliat Med. 2000;14:257–265
  13. Chiu TY, Hu WY, Lue BH, Cheng SY, Chen CY. Sedation for refractory symptoms of terminal cancer patients in Taiwan. J Pain Symptom Manage. 2001;21:467–472
  14. Sykes N, Thorns A. The use of opioids and sedatives at the end of life. Lancet Oncol. 2003;4:312–318
  15. Stone P, Phillips C, Spruyt O, Waight C. A comparison of the use of sedatives in a hospital support team and in a hospice. Palliat Med. 1997;11:140–144
  16. van der Wal G, van der Heide A, Onwuteaka-Philipsen BD, van der Maas PJ. Medische besluitvorming aan het einde van het leven. De praktijk en de toetsingsprocedure euthanasie. (Medical decision-making at the end of life: practices and the euthanasia review procedure). Utrecht: De Tijdstroom; 2003;
  17. van der Heide A, Onwuteaka-Philipsen BD, Rurup ML, et al. End-of-life practices in the Netherlands under the Euthanasia Act. N Engl J Med. 2007;356:1957–1965
  18. Ellershaw JE, Murphy D. The Liverpool Care Pathway (LCP) influencing the UK national agenda on care of the dying. Int J Palliat Nurs. 2005;11:132–134
  19. Morita T, Tsunoda J, Inoue S, Chihara S. Effects of high dose opioids and sedatives on survival in terminally ill cancer patients. J Pain Symptom Manage. 2001;21:282–289

 The authors confirm that there are no financial or personal relationships with other people or organizations that could have inappropriately influenced the work.

PII: S0885-3924(08)00139-5

doi: 10.1016/j.jpainsymman.2007.10.014

Journal of Pain and Symptom Management
Volume 36, Issue 3 , Pages 228-234 , September 2008

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