Journal of Pain and Symptom Management
Volume 36, Issue 4 , Pages 351-357 , October 2008

The Prevalence of Nocturnal Hypoxemia in Advanced Cancer

  • Andrew Wilcock, DM, FRCP

      Affiliations

    • Hayward House Macmillan Specialist Palliative Cancer Care Unit, Nottingham University Hospitals NHS Trust, Nottingham
    • Corresponding Author InformationCorresponding author: Andrew Wilcock, DM, FRCP, Hayward House Macmillan Specialist Palliative Cancer Care Unit, Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham NG5 1PB, United Kingdom.
    • ,
  • Ruth England, MRCP

      Affiliations

    • Hayward House Macmillan Specialist Palliative Cancer Care Unit, Nottingham University Hospitals NHS Trust, Nottingham
    • ,
  • Bisharat El Khoury, MRCGP

      Affiliations

    • Hayward House Macmillan Specialist Palliative Cancer Care Unit, Nottingham University Hospitals NHS Trust, Nottingham
    • ,
  • Jacky Frisby, MRCP

      Affiliations

    • Hayward House Macmillan Specialist Palliative Cancer Care Unit, Nottingham University Hospitals NHS Trust, Nottingham
    • ,
  • Paul Howard, MRCP

      Affiliations

    • Hayward House Macmillan Specialist Palliative Cancer Care Unit, Nottingham University Hospitals NHS Trust, Nottingham
    • ,
  • Sarah Bell, MRCP

      Affiliations

    • Hayward House Macmillan Specialist Palliative Cancer Care Unit, Nottingham University Hospitals NHS Trust, Nottingham
    • ,
  • CathAnn Manderson, RN

      Affiliations

    • Hayward House Macmillan Specialist Palliative Cancer Care Unit, Nottingham University Hospitals NHS Trust, Nottingham
    • ,
  • Vaughan Keeley, PhD, FRCP

      Affiliations

    • Nightingale Macmillan Unit, Derby Hospitals NHS Foundation Trust, Derby, United Kingdom
    • ,
  • William Kinnear, MD, FRCP

      Affiliations

    • Respiratory Medicine Department, Nottingham University Hospitals NHS Trust, Nottingham

,Accepted 14 November 2007.

References 

  1. Wagner LI, Cella D. Fatigue and cancer: causes, prevalence and treatment approaches. Br J Cancer. 2004;91:822–828
  2. Jenkins CA, Schulz M, Hanson J, Bruera E. Demographic, symptom, and medication profiles of cancer patients seen by a palliative care consult team in a tertiary referral hospital. J Pain Symptom Manage. 2000;19:174–184
  3. Stone P. The measurement, causes and effective management of cancer related fatigue. Int J Palliat Nurs. 2002;8:120–128
  4. Ng K, Von Gunten CF. Symptoms and attitudes of 100 consecutive patients admitted to an acute hospice/palliative care unit. J Pain and Symptom Manage. 1998;16(5):307–316
  5. Gay PC. Chronic obstructive pulmonary disease and sleep. Respir Care. 2004;49:39–51
  6. Roscoe JA, Kaufman ME, Matteson-Rusby SE, et al. Cancer-related fatigue and sleep disorders. Oncologist. 2007;12:35–42
  7. Moore P, Bardwell WA, Ancoli-Israel S, Dimsdale JE. Association between polysomnographic sleep measures and health-related quality of life in obstructive sleep apnoea. J Sleep Res. 2001;10:303–308
  8. Sforza E, Janssens JP, Rochat T, Ibanez V. Determinants of altered quality of life in patients with sleep-related breathing disorders. Eur Resp J. 2003;21:682–687
  9. Bedard MA, Montplaisir J, Richer F, Rouleau I, Malo J. Obstructive sleep apnea syndrome: pathogenesis of neuropsychological deficits. J Clin Exp Neuropsychol. 1991;13:950–964
  10. Roehrs T, Zorick F, Wittig R, Conway W, Roth T. Predictors of objective level of daytime sleepiness in patients with sleep-related breathing disorders. Chest. 1989;95:1202–1206
  11. Clark M, Cooper B, Singh S, et al. A survey of nocturnal hypoxemia and health related quality of life in patients with cryptogenic fibrosing alveolitis. Thorax. 2001;56:482–486
  12. Dudgeon DJ, Lertzman M, Askew GR. Physiological changes and clinical correlations of dyspnea in cancer outpatients. J Pain Symptom Manage. 2001;21:373–379
  13. Feathers LS, Wilcock A, Manderson C, Weller R, Tattersfield AE. Measuring inspiratory muscle weakness in patients with cancer and breathlessness. J Pain Symptom Manage. 2003;25:305–306
  14. Farney RJ, Walker JM, Cloward TV, Rhondeau S. Sleep disordered breathing associated with long-term opioid therapy. Chest. 2003;123:632–639
  15. Block AJ, Dolly FR, Slayton PC. Does flurazepam ingestion affect breathing and oxygenation during sleep in patients with chronic obstructive lung disease?. Am Rev Respir Dis. 1984;129:230–233
  16. Oken MM, Creech RH, Tormey DC, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982;5:649–655Available at http://www.ecog.org/general/perf_stat.htmlAccessed October 2007
  17. Watson L. A method for measuring SNIP (sniff nasal inspiratory pressure) using the PK Morgan Pmax monitor “Snips for a snip. Inspire. 1997;1:14–16
  18. Uldry C, Fitting J-W. Maximal values of sniff nasal inspiratory pressure in healthy subjects. Thorax. 1995;50:371–375
  19. Johns MW. A new method for measuring sleepiness: the Epworth Sleepiness Scale. Sleep. 1991;14:540–545
  20. Smets EMA, Garssen B, Bonke B, Haes de JCJM. The Multidimensional Fatigue Inventory (MFI): psychometric qualities of an instrument to assess fatigue. J Psychosom Res. 1995;39:315–325
  21. Ware JE, Snow KK, Kosinski M, Gandek B. SF-36 Health Survey manual and interpretation guide. Boston, MA: New England Medical Center, The Health Institute; 1993;
  22. American College of Chest Physicians . Clinical indications for noninvasive positive pressure ventilation in chronic respiratory failure due to restrictive lung disease, COPD and nocturnal hypoventilation—a consensus conference report. Chest. 1999;116:521–534
  23. Anderson KO, Getto CJ, Mendosa TR, et al. Fatigue and sleep disturbance in patients with cancer, patients with clinical depression, and community-dwelling adults. J Pain Symptom Manage. 2003;25:307–318
  24. Rafanon AL, Golish JA, Dinner DS, Hague LK, Arroliga AC. Nocturnal hypoxemia is common in primary pulmonary hypertension. Chest. 2001;120:894–899
  25. Chaouat A, Weitzenblum E, Kessler R, et al. Outcome of COPD patients with mild daytime hypoxemia with or without sleep-related oxygen desaturation. Eur Respir J. 2001;17:848–855
  26. Scottish Intercollegiate Guidelines Network (SIGN). Management of obstructive sleep apnoea/hypopnoea syndrome in adults. A national clinical guideline. Edinburgh (Scotland): Scottish Intercollegiate Guidelines Network (SIGN); 2003;(SIGN publication; no. 73)
  27. Mosconi P, Cifani S, Crispino S, Fossati R, Apolone G. The performance of SF-36 health survey in patients with laryngeal cancer. Head Neck. 2000;22:175–182
  28. Ware JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992;30:473–483
  29. Groenvold M, Petersen MA, Aaronson NK, et al. The development of the EORTC QLQ-C15-PAL: a shortened questionnaire for cancer patients in palliative care. Eur J Cancer. 2006;42:55–64

 This project received funding from the Association for Palliative Medicine of Great Britain and Ireland/Napp Research Bursary, Hayward House Cancer Care Trust, Next, Peel Medical Research Trust, and the Royal Society of Medicine.

PII: S0885-3924(08)00203-0

doi: 10.1016/j.jpainsymman.2007.11.007

Journal of Pain and Symptom Management
Volume 36, Issue 4 , Pages 351-357 , October 2008

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