Journal of Pain and Symptom Management
Volume 36, Issue 5 , Pages 468-479 , November 2008

Treatment-Related Symptom Clusters in Breast Cancer: A Secondary Analysis

  • Hee-Ju Kim, PhD, RN

      Affiliations

    • University of Ulsan, Ulsan, South Korea
    • Corresponding Author InformationAddress correspondence to: Hee-Ju Kim, PhD, RN, University of Ulsan Department of Nursing, Nam-Gu Dae-Hak-Ro 102, Ulsan 680-749, South Korea.
  • ,
  • Andrea M. Barsevick, PhD, RN, AOCN

      Affiliations

    • Fox Chase Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA
  • ,
  • Lorraine Tulman, DNSc, RN

      Affiliations

    • School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA
  • ,
  • Paul A. McDermott, PhD, ABAP

      Affiliations

    • Graduate School of Education, University of Pennsylvania, Philadelphia, Pennsylvania, USA

,Accepted 23 November 2007.

References 

  1. Cooley ME, Short TH, Moriarty HJ. Symptom prevalence, distress, and change over time in adults receiving treatment for lung cancer. Psychooncology. 2003;12(7):694–708
  2. Given CW, Given B, Azzouz F, Kozachik S, Stommel M. Predictors of pain and fatigue in the year following diagnosis among elderly cancer patients. J Pain Symptom Manage. 2001;21(6):456–466
  3. Given B, Given CW, Azzouz F, Stommel M. Physical functioning of elderly cancer patients prior to diagnosis and following initial treatment. Nurs Res. 2001;50(4):222–232
  4. Sarna L. Correlates of symptom distress in women with lung cancer. Cancer Pract. 1993;1(1):21–28
  5. Dodd MJ, Miaskowski C, Paul SM. Symptom clusters and their effect on the functional status of patients with cancer. Oncol Nurs Forum. 2001;28(3):465–470
  6. Kim H-J, McGuire DB, Tulman L, Barsevick AM. Symptom clusters: concept analysis and clinical implications for cancer nursing. Cancer Nurs. 2005;28(4):270–282
  7. American Cancer Society. Breast cancer facts & figures (online document). 2005. Accessed March 6, 2006. Available at http://www.cancer.org/downloads/STT/CAFF2005BrF.pdf
  8. Akechi T, Kugaya A, Okamura H, Yamawaki S, Uchitomi Y. Fatigue and its associated factors in ambulatory cancer patients: a preliminary study. J Pain Symptom Manage. 1999;17(1):42–48
  9. Berger AM. Patterns of fatigue and activity and rest during adjuvant breast cancer chemotherapy. Oncol Nurs Forum. 1998;25(1):51–62
  10. Gift AG, Jablonski A, Stommel M, Given W. Symptom clusters in elderly patients with lung cancer. Oncol Nurs Forum. 2004;31(2):203–210
  11. Jacobsen PB, Hann DM, Azzarello LM, et al. Fatigue in women receiving adjuvant chemotherapy for breast cancer: characteristics, course, and correlates. J Pain Symptom Manage. 1999;18(4):233–242
  12. Hoskins CN. Breast cancer treatment-related patterns in side effects, psychological distress, and perceived health status. Oncol Nurs Forum. 1997;24(9):1575–1583
  13. Barsevick AM, Dudley W, Beck S, et al. A randomized clinical trial of energy conservation for patients with cancer-related fatigue. Cancer. 2004;100(6):1302–1310
  14. Meek PM, Nail LM, Jones LS. Internal consistency reliability and construct validity of a new measure of cancer treatment related fatigue: the General Fatigue Scale(GFS). [abstract] Oncol Nurs Forum. 1997;24:334
  15. McNair DM, Lorr M, Droppleman LF. Profile of Mood States, Revised (POMS). San Diego, CA: EdITS/Educational and Industrial Testing Service; 1981;
  16. Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193–213
  17. Nail LM, Jones LS, Greene D, Schipper DL, Jensen R. Use and perceived efficacy of self-care activities in patients receiving chemotherapy. Oncol Nurs Forum. 1991;18(5):883–887
  18. Gorsuch RL. Factor analysis. 2nd ed.. Hillsdale, NJ: Erlbaum; 1983;
  19. Geweke JF, Singleton KI. Interpreting the likelihood of ratio statistics in factor models when sample size is small. J Am Stat Assoc. 1980;75:133–137
  20. Horn JL. A rationale and test for the number of factors in factor analysis. Psychometrika. 1965;30:179–185
  21. Velicer WF. Determining the number of components from the matrix of partial correlations. Psychometrika. 1976;41:321–327
  22. Spector PE. Summated rating scale construction: an introduction. Newbury Park, CA: Sage; 1992;
  23. Tabachnick BG, Fidell LS. Using multivariate statistics. 4th ed.. New York: HarperCollins College Publisher; 2001;
  24. Guadagnoli E, Velicer W. A comparison of pattern matching indices. Multivariate Behav Res. 1991;26:323–343
  25. Wood JM, Tataryn DJ, Gorsuch RL. Effects of under- and overextraction on principal axis factor analysis with varimax rotation. Psychol Methods. 1996;1:354–365
  26. Sarna L, Brecht ML. Dimensions of symptom distress in women with advanced lung cancer: a factor analysis. Heart Lung. 1997;26(1):23–30
  27. Bender CM, Ergun FS, Rosenzweig MQ, Cohen SM, Sereika SM. Symptom clusters in breast cancer across 3 phases of the disease. Cancer Nurs. 2005;28(3):219–225
  28. Bower JE, Ganz PA, Desmond KA, et al. Fatigue in breast cancer survivors: occurrence, correlates, and impact on quality of life. J Clin Oncol. 2000;18(4):743–753
  29. Cleeland CS, Bennett GJ, Dantzer R, et al. Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism? A cytokine-immunologic model of cancer symptoms. Cancer. 2003;97(11):2919–2925
  30. Lee BN, Dantzer R, Langley KE, et al. A cytokine-based neuroimmunologic mechanism of cancer-related symptoms. Neuroimmunomodulation. 2004;11(5):279–292
  31. Miaskowski C, Aouizerat BE. Is there a biological basis for the clustering of symptoms. Semin Oncol Nurs. 2007;23(2):99–105
  32. Walsh D, Rybicki L. Symptom clustering in advanced cancer. Support Care Cancer. 2006;14(8):831–836
  33. Chen ML, Tseng HC. Symptom clusters in cancer patients. Support Care Cancer. 2006;14(8):825–830
  34. Broeckel JA, Jacobsen PB, Horton J, Balducci L, Lyman GH. Characteristics and correlates of fatigue after adjuvant chemotherapy for breast cancer. J Clin Oncol. 1998;16(5):1689–1696
  35. Chang VT, Hwang SS, Feuerman M, Kasimis BS. Symptom and quality of life survey of medical oncology patients at a Veterans Affairs medical center: a role for symptom assessment. Cancer. 2000;88(5):1175–1183

 The primary study was supported by the National Institutes of Health—National Institute of Nursing Research (R01NR04573). The present study was supported by Sigma Theta Tau International and the Xi Chapter of Sigma Theta Tau International.

PII: S0885-3924(08)00210-8

doi: 10.1016/j.jpainsymman.2007.11.011

Journal of Pain and Symptom Management
Volume 36, Issue 5 , Pages 468-479 , November 2008