Journal of Pain and Symptom Management
Volume 38, Issue 4 , Pages 522-532 , October 2009

Mucositis-Related Morbidity and Resource Utilization in Head and Neck Cancer Patients Receiving Radiation Therapy With or Without Chemotherapy

  • Barbara A. Murphy, MD

      Affiliations

    • Vanderbilt University, Nashville, Tennessee, USA
    • Corresponding Author InformationAddress correspondence to: Barbara A. Murphy, MD, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, 777 Preston Research Building, Nashville, TN 37232-5536, USA.
    • ,
  • Jennifer L. Beaumont, MS

      Affiliations

    • Center on Outcomes, Research and Education, Evanston Northwestern Healthcare, Evanston, Illinois, USA
    • ,
  • John Isitt, MS

      Affiliations

    • Amgen, Inc., Thousand Oaks, California, USA
    • ,
  • Adam S. Garden, MD

      Affiliations

    • University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA
    • ,
  • Clement K. Gwede, PhD, MPH

      Affiliations

    • Moffitt Cancer Center and the University of South Florida, Tampa, Florida, USA
    • ,
  • Andy M. Trotti, MD

      Affiliations

    • Moffitt Cancer Center and the University of South Florida, Tampa, Florida, USA
    • ,
  • Ruby F. Meredith, MD

      Affiliations

    • University of Alabama, Birmingham, Alabama, USA
    • ,
  • Joel B. Epstein, DMD, MSD

      Affiliations

    • University of Illinois, Chicago, Illinois, USA
    • ,
  • Quynh-Thu Le, MD

      Affiliations

    • Stanford University, Stanford, California, USA
    • ,
  • David M. Brizel, MD

      Affiliations

    • Duke University, Durham, North Carolina, USA
    • ,
  • Lisa A. Bellm, MIM

      Affiliations

    • Independent Consultant, San Francisco, California, USA
    • ,
  • Nancy Wells, DNSc

      Affiliations

    • Vanderbilt University, Nashville, Tennessee, USA
    • ,
  • David Cella, PhD

      Affiliations

    • Center on Outcomes, Research and Education, Evanston Northwestern Healthcare, Evanston, Illinois, USA

,Accepted 2 January 2009.

  • Image Result

    Maximum severity of mouth and throat soreness by type of radiation therapy. The rates of severe pain were not significantly different (P=0.175 by Fisher's exact test) with regard to radiation techniqu

    Maximum severity of mouth and throat soreness by type of radiation therapy. The rates of severe pain were not significantly different (P=0.175 by Fisher's exact test) with regard to radiation technique. Conventional RT=conventional RT±CB.

  • Image Result
    Opioid use. a) Route of administration. b) Severity of mouth and throat soreness over time, according to opioid use. The overall test for the effect of time was statistically significant (P<0.001 b

    Opioid use. a) Route of administration. b) Severity of mouth and throat soreness over time, according to opioid use. The overall test for the effect of time was statistically significant (P<0.001 by general linear model). Changes in mouth and throat soreness at each time point compared with baseline were also statistically significant (P<0.001 by general linear model). c) Mean OMWQ-HN scores over time, according to opioid use. Scores among patients taking opioids were significantly greater than those among patients not taking opioids at Weeks 1–2 (P=0.025) and 3–4 (P=0.001), and were not significantly different at Weeks 5–6 (P=0.256).

  • Image Result
    Hospitalizations and their relationship with mucositis.

    Hospitalizations and their relationship with mucositis.

 This study was supported by Amgen, Inc.

PII: S0885-3924(09)00534-X

doi: 10.1016/j.jpainsymman.2008.12.004

Journal of Pain and Symptom Management
Volume 38, Issue 4 , Pages 522-532 , October 2009

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