Journal of Pain and Symptom Management
Volume 38, Issue 4 , Pages 522-532 , October 2009

Mucositis-Related Morbidity and Resource Utilization in Head and Neck Cancer Patients Receiving Radiation Therapy With or Without Chemotherapy

  • Barbara A. Murphy, MD

      Affiliations

    • Vanderbilt University, Nashville, Tennessee, USA
    • Corresponding Author InformationAddress correspondence to: Barbara A. Murphy, MD, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, 777 Preston Research Building, Nashville, TN 37232-5536, USA.
    • ,
  • Jennifer L. Beaumont, MS

      Affiliations

    • Center on Outcomes, Research and Education, Evanston Northwestern Healthcare, Evanston, Illinois, USA
    • ,
  • John Isitt, MS

      Affiliations

    • Amgen, Inc., Thousand Oaks, California, USA
    • ,
  • Adam S. Garden, MD

      Affiliations

    • University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA
    • ,
  • Clement K. Gwede, PhD, MPH

      Affiliations

    • Moffitt Cancer Center and the University of South Florida, Tampa, Florida, USA
    • ,
  • Andy M. Trotti, MD

      Affiliations

    • Moffitt Cancer Center and the University of South Florida, Tampa, Florida, USA
    • ,
  • Ruby F. Meredith, MD

      Affiliations

    • University of Alabama, Birmingham, Alabama, USA
    • ,
  • Joel B. Epstein, DMD, MSD

      Affiliations

    • University of Illinois, Chicago, Illinois, USA
    • ,
  • Quynh-Thu Le, MD

      Affiliations

    • Stanford University, Stanford, California, USA
    • ,
  • David M. Brizel, MD

      Affiliations

    • Duke University, Durham, North Carolina, USA
    • ,
  • Lisa A. Bellm, MIM

      Affiliations

    • Independent Consultant, San Francisco, California, USA
    • ,
  • Nancy Wells, DNSc

      Affiliations

    • Vanderbilt University, Nashville, Tennessee, USA
    • ,
  • David Cella, PhD

      Affiliations

    • Center on Outcomes, Research and Education, Evanston Northwestern Healthcare, Evanston, Illinois, USA

,Accepted 2 January 2009.

References 

  1. Rose-Ped AM, Bellm LA, Epstein JB, et al. Complications of radiation therapy for head and neck cancers. The patient's perspective. Cancer Nurs. 2002;25:461–467quiz 468–469
  2. Sonis ST, Oster G, Fuchs H, et al. Oral mucositis and the clinical and economic outcomes of hematopoietic stem-cell transplantation. J Clin Oncol. 2001;19:2201–2205
  3. Peterman A, Cella D, Glandon G, Dobrez D, Yount S. Mucositis in head and neck cancer: economic and quality-of-life outcomes. J Natl Cancer Inst Monogr. 2001;29:45–51
  4. Trotti A, Bellm LA, Epstein JB, et al. Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review. Radiother Oncol. 2003;66:253–262
  5. List MA, D'Antonio LL, Cella DF, et al. The Performance Status Scale for Head and Neck Cancer Patients and the Functional Assessment of Cancer Therapy-Head and Neck Scale. A study of utility and validity. Cancer. 1996;77:2294–2301
  6. Bjordal K, Hammerlid E, Ahlner-Elmqvist M, et al. Quality of life in head and neck cancer patients: validation of the European organization for research and treatment of cancer quality of life questionnaire-H&N35. J Clin Oncol. 1999;17:1008–1019
  7. Epstein JB, Beaumont JL, Gwede CK, et al. Longitudinal evaluation of the oral mucositis weekly questionnaire-head and neck cancer, a patient-reported outcomes questionnaire. Cancer. 2007;109:1914–1922
  8. Wong PC, Dodd MJ, Miaskowski C, et al. Mucositis pain induced by radiation therapy: prevalence, severity, and use of self-care behaviors. J Pain Symptom Manage. 2006;32:27–37
  9. Murphy BA. Clinical and economic consequences of mucositis induced by chemotherapy and/or radiation therapy. J Support Oncol. 2007;5:13–21
  10. Rosenthal DI. Consequences of mucositis-induced treatment breaks and dose reductions on head and neck cancer treatment outcomes. J Support Oncol. 2007;5:23–31
  11. Milano MT, Vokes EE, Kao J, et al. Intensity-modulated radiation therapy in advanced head and neck patients treated with intensive chemoradiotherapy: preliminary experience and future directions. Int J Oncol. 2006;28:1141–1151
  12. Hodge CW, Bentzen SM, Wong G, et al. Are we influencing outcome in oropharynx cancer with intensity-modulated radiotherapy? An inter-era comparison. Int J Radiat Oncol Biol Phys. 2007;69:1032–1041
  13. Urbano TG, Clark CH, Hansen VN, et al. Intensity modulated radiotherapy (IMRT) in locally advanced thyroid cancer: acute toxicity results of a phase I study. Radiother Oncol. 2007;85:58–63
  14. HCUPnet . A tool for identifying, tracking, and analyzing national hospital statistics. Available from http://hcup.ahrq.gov/HCUPnet.jsp2004;Accessed January 31, 2007
  15. Elting LS, Cooksley C, Chambers M, et al. The burdens of cancer therapy. Clinical and economic outcomes of chemotherapy-induced mucositis. Cancer. 2003;98:1531–1539

 This study was supported by Amgen, Inc.

PII: S0885-3924(09)00534-X

doi: 10.1016/j.jpainsymman.2008.12.004

Journal of Pain and Symptom Management
Volume 38, Issue 4 , Pages 522-532 , October 2009

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