Journal of Pain and Symptom Management
Volume 38, Issue 6 , Pages 860-870 , December 2009

Sleep-Wake Disturbances in Patients with Advanced Cancer and Their Family Carers

  • Jane Gibbins, MBChB, MRCP

      Affiliations

    • Department of Palliative Medicine, University of Bristol and University Hospital Bristol, Bristol Haematology and Oncology Centre, Bristol, United Kingdom
    • Corresponding Author InformationAddress correspondence to: Jane Gibbins, MBChB, MRCP, Department of Palliative Medicine, University of Bristol, Bristol Haematology and Oncology Centre, Horfield Road, Bristol BS2 8ED, United Kingdom.
    • ,
  • Rachel McCoubrie, MBBS, MRCP, MSc

      Affiliations

    • Department of Palliative Medicine, University of Bristol and University Hospital Bristol, Bristol Haematology and Oncology Centre, Bristol, United Kingdom
    • ,
  • Adrian H. Kendrick, BSc, PhD

      Affiliations

    • Department of Respiratory Medicine, University Hospitals Bristol, Bristol, United Kingdom
    • ,
  • Gaye Senior-Smith, BSc, MSc

      Affiliations

    • Department of Palliative Medicine, University of Bristol and University Hospital Bristol, Bristol Haematology and Oncology Centre, Bristol, United Kingdom
    • ,
  • Andrew N. Davies, MBBS, MRCP, MSc, MD

      Affiliations

    • Department of Palliative Medicine, Royal Marsden NHS Foundation Hospital, Surrey, United Kingdom
    • ,
  • Geoffrey W. Hanks, DSc (Med), BSc, MB, FRCP, FRCPE, FFPM

      Affiliations

    • Department of Palliative Medicine, University of Bristol and University Hospital Bristol, Bristol Haematology and Oncology Centre, Bristol, United Kingdom

,Accepted 28 April 2009.

References 

  1. Beck SL, Schwartz AL, Towsley G, Uddley W, Barsevick A. Psychometric evaluation of the Pittsburgh Sleep Quality Index in cancer patients. J Pain Symptom Manage. 2004;27:140–148
  2. Parker KP, Bliwise DL, Riberio M, et al. Sleep/wake patterns of individuals with advanced cancer measured by ambulatory polysomnography. J Clin Oncol. 2008;26:2464–2472
  3. Akechi T, Okuyama T, Akizuki N, et al. Associated and predictive factors of sleep disturbance in advanced cancer patients. Psychooncology. 2007;16:888–894
  4. Berger AM, Parker KP, Young-McCaughan S, et al. Sleep wake disturbance in people with cancer and their caregivers: state of the science. Oncol Nurs Forum. 2005;32:E98–E126
  5. Davidson J, MacLean A, Brundage M, Schulze K. Sleep disturbance in cancer patients. Soc Sci Med. 2002;54:1309–1321
  6. Mystakidou K, Parpa E, Tsilika E, et al. The relationship of subjective sleep quality, pain and quality of life in advanced cancer patients. Sleep. 2007;30:737–742
  7. Silberfarb PM, Hauri PJ, Oxman TE, Schnurr P. Assessment of sleep in patients with lung cancer and breast cancer. J Clin Oncol. 1993;11:997–1004
  8. Savard J, Morin C. Insomnia in the context of cancer: a review of a neglected problem. J Clin Oncol. 2001;19:895–908
  9. Engstrom C, Strohl R, Rose L, Lewandowski L, Stefanek M. Sleep alterations in cancer patients. Cancer Nurs. 1999;22:143–148
  10. Whelan T, Mohide E, Willan A, et al. The supportive care needs of newly diagnosed cancer patients attending a regional cancer center. Cancer. 1997;80:1518–1524
  11. Anderson K, Getto C, Mendoza T, et al. Fatigue and sleep disturbance in patients with cancer, patients with clinical depression, and community-dwelling adults. J Pain Symptom Manage. 2003;25:307–318
  12. Weitzner M, Jacobsen P, Wagner H, Friedland J, Cox C. The Caregiver Quality of Life Index-Cancer (CQOLC) scale: development and validation of an instrument to measure quality of life of the family caregiver of patients with cancer. Qual Life Res. 1999;8:55–63
  13. Miaskowski C, Lee K. Pain, fatigue and sleep disturbances in oncology outpatients receiving radiation therapy for bone metastasis: a pilot study. J Pain Symptom Manage. 1999;17:320–332
  14. Carter P. Caregivers' descriptions of sleep changes and depressive symptoms. Oncol Nurs Forum. 2002;29:1277–1283
  15. Fletcher B, Paul S, Dodd M, et al. Prevalence, severity, and impact of symptoms on female family caregivers of patients at the initiation of radiation therapy for prostate cancer. J Clin Oncol. 2008;26:599–605
  16. Passik S, Whitcomb L, Kirsh K, Theobald D. An unsuccessful attempt to develop a single-item screen for insomnia in cancer patients. J Pain Symptom Manage. 2003;25:284–287
  17. Sadeh A, Ahuri P, Kripke D, Lavie P. The role of actigraphy in the evaluation of sleep disorders. Sleep. 1995;18:228–302
  18. Babin L, Lee S, Halko S, Boudreau AC, George CFP. Determining sleep-wake activity using Actiwatch. [abstract] Sleep. 1997;20(Supplement):178
  19. Kushida C, Chang C, Gadkary C, et al. Comparison of actigraphic, polysomnographic and subjective assessment of sleep parameters in sleep-disordered patients. Sleep Med. 2001;2:389–396
  20. Littner M, Kushida CA, Anderson WM, et al. Practice parameters for the role of actigraphy in the study of sleep and circadian rhythms: an update for 2002. Sleep. 2003;26:337–341
  21. Ancoli-Israel S, Cole R, Alessi C, et al. The role of actigraphy in the study of sleep and circadian rhythms. Sleep. 2003;26:342–392
  22. Johns M. A new method for measuring daytime sleepiness: the Epworth Sleepiness Scale. Sleep. 1991;14:540–545
  23. Zigmond AS, Snaith RP. The Hospital Anxiety and Depression Scale. Acta Psychiatr Scand. 1983;67:361–370
  24. Ware JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992;30:473–483
  25. Portenoy RK, Thaler HT, Kornblith AB, et al. The Memorial Symptom Assessment Scale: an instrument for the evaluation of symptom prevalence, characteristics and distress. Eur J Cancer. 1994;30A:1326–1336
  26. Walsh D, Donnelly S, Rybicki L. The symptoms of advanced cancer: relationship to age, gender and performance status in 1000 patients. Support Care Cancer. 2000;8:175–179
  27. Carter PA. Family caregivers' sleep loss and depression over time. Cancer Nurs. 2003;26:253–259
  28. Savard J, Simard S, Blanchet J, Ivers H, Morin CM. Prevalence, clinical characteristics, and risk factors for insomnia in the context of breast cancer. Sleep. 2001;24:582–590
  29. Mercadante S, Girelli D, Casuccio A. Sleep disorders in advanced cancer patients: prevalence and factors associated. Support Care Cancer. 2004;12:355–359
  30. Mystakidou K, Parpa E, Tsilika E, et al. Sleep quality in advanced cancer patients. J Psychosom Res. 2007;62:527–533
  31. Wilcock A, England R, El Koury B, et al. The prevalence of nocturnal hypoxemia in advanced cancer. J Pain Symptom Manage. 2008;36:351–357
  32. Le Guen Y, Gagnadoux F, Hureaux J, et al. Sleep disturbances and impaired daytime functioning in outpatients with newly diagnosed lung cancer. Lung Cancer. 2007;58:139–143
  33. Carter PA, Change BL. Sleep and depression in cancer caregivers. Cancer Nurs. 2002;23:410–415
  34. Paquet J, Kawinska A, Carrier J. Wake detection capacity of actigraphy during sleep. Sleep. 2007;30:1362–1369
  35. Iber C, Redline S, Kaplan Gilpin A, et al. Polysomnography performed in the unattended home versus the attended laboratory setting. Sleep. 2004;20:1077–1085
  36. Gale J, Signal T, Gander P. Statistical artifact in the validation of actigraphy. Sleep. 2005;28:1017–1018

 The University Hospitals Bristol NHS Foundation Trust Charitable Trust provided a grant to the Department of Palliative Medicine to purchase the Actiwatches. The Department of Palliative Medicine has also received funding from Macmillan Cancer Support and the European Palliative Care Research Collaborative. The authors declare no conflicts of interest.

PII: S0885-3924(09)00709-X

doi: 10.1016/j.jpainsymman.2009.04.025

Journal of Pain and Symptom Management
Volume 38, Issue 6 , Pages 860-870 , December 2009

Article Tools

* Image Usage & Resolution