Journal of Pain and Symptom Management
Volume 39, Issue 1 , Pages 116-125 , January 2010

Efficacy and Side Effects of Diclofenac Patch in Treatment of Patients with Myofascial Pain Syndrome of the Upper Trapezius

  • Lin-Fen Hsieh, MD

      Affiliations

    • Department of Physical Medicine and Rehabilitation, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
    • School of Medicine, Fu Jen Catholic University, Taipei, Taiwan
    • Corresponding Author InformationAddress correspondence to: Lin-Fen Hsieh, MD, Department of Physical Medicine and Rehabilitation, Shin Kong Wu Ho-Su Memorial Hospital, No. 95, Wen Chang Road, Shih Lin District, Taipei, Taiwan.
  • ,
  • Chang-Zern Hong, MD

      Affiliations

    • Department of Physical Therapy, Hung-Kuang University, Sha Lu, Taichung, Taiwan
  • ,
  • Shiuan-Horng Chern, MD

      Affiliations

    • Department of Physical Medicine and Rehabilitation, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
  • ,
  • Chen-Chiao Chen, MD

      Affiliations

    • Department of Physical Medicine and Rehabilitation, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan

,Accepted 14 May 2009.

References 

  1. Simons DG, Travell JG, Simons LS. In: Travell & Simons's myofascial pain and dysfunction: The trigger point manual. Vol. 2. 2nd ed.. Baltimore: Lippincott Williams & Wilkins; 1999;
  2. Kao MJ, Han TI, Kuan TS, et al. Myofascial trigger points in early life. Arch Phys Med Rehabil. 2007;88:251–254
  3. Hong CZ, Simons DG. Pathophysiologic and electrophysiologic mechanism of myofascial trigger points. Arch Phys Med Rehabil. 1998;79:863–872
  4. Borg-Stein J, Simons DG. Focused review: myofascial pain. Arch Phys Med Rehabil. 2002;83:S40–S49
  5. Travell JG, Simons DG. Travell & Simons' myofascial pain and dysfunction: The trigger point manual. Vol. 1. Baltimore: Williams & Wilkins; 1992;
  6. Wheeler AH, Goolkasian P, Gretz SS. A randomised, double blind, prospective, pilot study of botulinum toxin injection for refractory, unilateral, cervicothoracic, paraspinal, myofascial pain syndrome. Spine. 1998;23:1882–1888
  7. Hong CZ. Myofascial pain therapy. J Musculoskelet Pain. 2004;12:37–43
  8. Rickards LD. The effectiveness of non-invasive treatments for active myofascial trigger point pain: a systematic review of the literature. Int J Osteopath Med. 2006;9:120–136
  9. Ong CKS, Tan CH, Seymour RA. An evidence-based update on non-steroidal anti-inflammatory drugs. Clin Med Res. 2007;5:19–34
  10. Gotzsche PC. Non-steroidal anti-inflammatory drugs. BMJ. 2000;320:1063–1070
  11. Funk CD. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science. 2001;294(5548):1871–1875
  12. Mason L, Moore RA, Edwards JE, Derry S, McQuay HJ. Topical NSAIDs for acute pain: a meta-analysis. BMC Fam Pract. 2004;5:10–18
  13. Mason L, Moore RA, Edwards JE, Derry S, McQuay HJ. Topical NSAIDs for chronic musculoskeletal pain: systematic review and meta-analysis. BMC Musculoskelet Disord. 2004;5:28–35
  14. Moore RA, Tramer MR, Carroll D, Wiffen PJ, McQuay HJ. Quantitative systematic review of topically applied non-steroidal anti-inflammatory drugs. BMJ. 1998;316:333–338
  15. Di Rienzo BL, Di Rienzo BA, D'Emilia M, Lauriello M, Coen TG. Topical versus systemic diclofenac in the treatment of temporomandibular joint dysfunction symptoms. Acta Otorhinolaryngol Ital. 2004;24:279–285
  16. Affaitati G, Vecchiet F, Lerza R, et al. Effects of topical diclofenac (DHEP plaster) on skin, subcutis and muscle pain thresholds in subjects without spontaneous pain. Drugs Exp Clin Res. 2001;27:69–76
  17. Fischer AA. Pressure threshold meter: its use for quantification of tender spots. Arch Phys Med Rehabil. 1986;67:836–838
  18. Fischer AA. Documentation of myofascial trigger points. Arch Phys Med Rehabil. 1988;69:286–291
  19. Reeves JL, Jaeger B, Graff-Radford SB. Reliability of the pressure algometer as a measure of myofascial trigger point sensitivity. Pain. 1986;24:313–321
  20. Vernon H, Mior S. The Neck Disability Index: a study of reliability and validity. J Manipulative Physiol Ther. 1991;14:409–415
  21. Magnusson BM, Anissimov YG, Cross SE, Roberts MS. Molecular size as the main determinant of solute maximum flux across the skin. J Invest Dermatol. 2004;122:993–999
  22. Sioufi A, Pommier F, Boschet F, et al. Percutaneous absorption of diclofenac in healthy volunteers after single and repeated topical application of diclofenac Emulgel. Biopharm Drug Dispos. 1994;15:441–449
  23. Müller M, Rastelli C, Ferri P, et al. Transdermal penetration of diclofenac after multiple epicutaneous administration. J Rheumatol. 1998;25(9):1833–1836
  24. Baer PA, Thomas LM, Shainhouse Z. Treatment of osteoarthritis of the knee with a topical diclofenac solution: a randomised controlled, 6-week trial. BMC Musculoskelet Disord. 2005;6:44–52
  25. Predel HG, Koll R, Pabst H, et al. Diclofenac patch for topical treatment of acute impact injuries: a randomised, double blind, placebo controlled, multicentre study. Br J Sports Med. 2004;38:318–323
  26. Niethard FU, Gold MS, Solomon GS, et al. Efficacy of topical diclofenac diethylamine gel in osteoarthritis of the knee. J Rheumatol. 2005;32:2384–2392
  27. Bookman AAM, Williams KSA, Shainhouse JZ, et al. Effects of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial. Can Med Assoc J. 2004;171:333–338
  28. Roth SH, Shainhouse JZ. Efficacy and safety of a topical diclofenac solution (pennsaid) in the treatment of primary osteoarthritis of the knee: a randomized, double-blind, vehicle-controlled clinical trial. Arch Intern Med. 2004;164:2017–2023
  29. Myburgh C, Larsen AH, Hartvigsen J. A systematic, critical review of manual palpation for identifying myofascial trigger points: evidence and clinical significance. Arch Phys Med Rehabil. 2008;89(6):1169–1176

 This research was supported by a grant from GlaxoSmithKline Pharmaceuticals, Ltd.

PII: S0885-3924(09)00745-3

doi: 10.1016/j.jpainsymman.2009.05.016

Journal of Pain and Symptom Management
Volume 39, Issue 1 , Pages 116-125 , January 2010