Journal of Pain and Symptom Management
Volume 40, Issue 2 , Pages 217-223 , August 2010

Age-Associated Differences in Fatigue Among Patients with Cancer

Portions of these findings were presented at the 2008 meeting of the Society for Behavioral Medicine.

  • Zeeshan Butt, PhD

      Affiliations

    • Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    • Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    • Institute for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    • Corresponding Author InformationAddress correspondence to: Zeeshan Butt, PhD, Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, 750 N. Lake Shore Drive, 10th Floor, Chicago, IL 60611, USA.
    • ,
  • Arati V. Rao, MD

      Affiliations

    • Division of Medical Oncology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    • ,
  • Jin-Shei Lai, PhD

      Affiliations

    • Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    • Institute for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    • Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    • ,
  • Amy P. Abernethy, MD

      Affiliations

    • Division of Medical Oncology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    • ,
  • Sarah K. Rosenbloom, PhD

      Affiliations

    • Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    • Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    • ,
  • David Cella, PhD

      Affiliations

    • Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    • Institute for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    • Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

,Accepted 19 January 2010.

References 

  1. Wagner LI, Cella D. Fatigue and cancer: causes, prevalence and treatment approaches. Br J Cancer. 2004;91:822–828
  2. Butt Z, Rosenbloom SK, Abernethy AP, et al. Fatigue is the most important symptom for advanced cancer patients who have had chemotherapy. J Natl Compr Canc Netw. 2008;6:448–455
  3. Cella D, Lai JS, Chang CH, Peterman A, Slavin M. Fatigue in cancer patients compared with fatigue in the general United States population. Cancer. 2002;94:528–538
  4. Beghe C, Wilson A, Ershler WB. Prevalence and outcomes of anemia in geriatrics: a systematic review of the literature. Am J Med. 2004;116(Suppl 7A):3S–10S
  5. Pujade-Lauraine E, Gascon P. The burden of anaemia in patients with cancer. Oncology. 2004;67(Suppl 1):1–4
  6. Vogelzang NJ, Breitbart W, Cella D, et al. Patient, caregiver, and oncologist perceptions of cancer-related fatigue: results of a tripart assessment survey. The Fatigue Coalition. Semin Hematol. 1997;34:4–12
  7. Agnihotri P, Telfer M, Butt Z, et al. Chronic anemia and fatigue in elderly patients: results of a randomized, double-blind, placebo-controlled, crossover exploratory study with epoetin alfa. J Am Geriatr Soc. 2007;55:1557–1565
  8. Cella D, Kallich J, McDermott A, Xu X. The longitudinal relationship of hemoglobin, fatigue and quality of life in anemic cancer patients: results from five randomized clinical trials. Ann Oncol. 2004;15:979–986
  9. Cella D, Zagari MJ, Vandoros C, et al. Epoetin alfa treatment results in clinically significant improvements in quality of life in anemic cancer patients when referenced to the general population. J Clin Oncol. 2003;21:366–373
  10. Yellen SB, Cella DF, Webster K, Blendowski C, Kaplan E. Measuring fatigue and other anemia-related symptoms with the Functional Assessment of Cancer Therapy (FACT) measurement system. J Pain Symptom Manage. 1997;13:63–74
  11. Lai JS, Cella D, Dineen K, et al. An item bank was created to improve the measurement of cancer-related fatigue. J Clin Epidemiol. 2005;58:190–197
  12. Lai JS, Crane PK, Cella D. Factor analysis techniques for assessing sufficient unidimensionality of cancer related fatigue. Qual Life Res. 2006;15:1179–1190
  13. Cella D, Eton DT, Lai JS, Peterman AH, Merkel DE. Combining anchor and distribution-based methods to derive minimal clinically important differences on the Functional Assessment of Cancer Therapy (FACT) anemia and fatigue scales. J Pain Symptom Manage. 2002;24:547–561
  14. PASW for Windows. Rel 17.02. Chicago, IL: 2009.
  15. Oken MM, Creech RH, Tormey DC, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982;5:649–655
  16. Butt Z, Cella D. Relationship of hemoglobin, fatigue, and quality of life in anemic cancer patients. In:  Nowrousian MR editors. Recombinant human erythropoietin (rhEPO) in clinical oncology: Scientific and clinical aspects of anemia in cancer. New York: Springer-Verlag; 2008;p. 369–392
  17. Thome B, Dykes AK, Hallberg IR. Quality of life in old people with and without cancer. Qual Life Res. 2004;13:1067–1080
  18. Aapro MS, Cella D, Zagari M. Age, anemia, and fatigue. Semin Oncol. 2002;29:55–59
  19. Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC. The prevalence of anemia in persons age 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood. 2004;104:2263–2268
  20. Lipman AJ, Lawrence DP. The management of fatigue in cancer patients. Oncology. 2004;18:1527–1534
  21. Jacobsen PB. Assessment of fatigue in cancer patients. J Natl Cancer Inst Monogr. 2004;93–97
  22. Mock V, Atkinson A, Barsevick AM, et al. Cancer-related fatigue. Clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2007;5:1054–1078
  23. Levy M. Cancer fatigue: a review for psychiatrists. Gen Hosp Psychiatry. 2008;30:233–244
  24. Schwartz CE, Bode R, Repucci N, et al. The clinical significance of adaptation to changing health: a meta-analysis of response shift. Qual Life Res. 2006;15:1533–1550
  25. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:M146–M156
  26. Brown LF, Kroenke K. Cancer-related fatigue and its associations with depression and anxiety: a systematic review. Psychosomatics. 2009;50:440–447

 Funding source: A subset of the data analyzed for this study was collected as part of National Institutes of Health (NIH) R01 CA60068 (Principal Investigator: David Cella, PhD). Manuscript preparation supported in part by grant UL1RR025741 from the National Center for Research Resources, NIH.

 Disclosures: Dr. Butt has received grant support from and served as a consultant for Ortho Biotech and has served as a consultant for Johnson & Johnson. Dr. Cella has received grant support from Ortho Biotech. The other authors have no disclosures.

PII: S0885-3924(10)00312-X

doi: 10.1016/j.jpainsymman.2009.12.016

Journal of Pain and Symptom Management
Volume 40, Issue 2 , Pages 217-223 , August 2010

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