Journal of Pain and Symptom Management
Volume 40, Issue 2 , Pages 200-216 , August 2010

Efficacy of an Intervention for Fatigue and Sleep Disturbance During Cancer Chemotherapy

  • Andrea Barsevick, PhD, RN, AOCN, FAAN

      Affiliations

    • Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    • Corresponding Author InformationAddress correspondence to: Andrea Barsevick, PhD, RN, AOCN, FAAN, Fox Chase Cancer Center, 510 Township Line Road, Cheltenham, PA 19012, USA.
  • ,
  • Susan L. Beck, PhD, RN, FAAN

      Affiliations

    • University of Utah College of Nursing, Salt Lake City, Utah, USA
  • ,
  • William N. Dudley, PhD

      Affiliations

    • The School of Health and Human Performance Office of Research, The University of North Carolina at Greensboro, Greensboro, North Carolina, USA
  • ,
  • Bob Wong, PhD

      Affiliations

    • University of Utah College of Nursing, Salt Lake City, Utah, USA
  • ,
  • Ann M. Berger, PhD, RN, AOCNS, FAAN

      Affiliations

    • University of Nebraska Medical Center, Omaha, Nebraska, USA
  • ,
  • Kyra Whitmer, PhD, RN

      Affiliations

    • College of Nursing, University of Cincinnati, Cincinnati, Ohio, USA
  • ,
  • Tracey Newhall, RN, BS, OCN

      Affiliations

    • Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
  • ,
  • Susan Brown, RN, OCN, CCRP

      Affiliations

    • Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
  • ,
  • Katie Stewart, MSPH

      Affiliations

    • Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

,Accepted 19 January 2010.

References 

  1. Barsevick AM. The concept of symptom cluster. Semin Oncol Nurs. 2007;23(2):89–98
  2. Barsevick AM. The elusive concept of the symptom cluster. Oncol Nurs Forum. 2007;34(5):971–980Online
  3. Barsevick AM, Dudley W, Beck S, et al. A randomized clinical trial of energy conservation for cancer-related fatigue. Cancer. 2004;100:1302–1310
  4. Bower JE, Ganz PA, Desmond KA, et al. Fatigue in breast cancer survivors: occurrence, correlates, and impact on quality of life. J Clin Oncol. 2000;18(4):743–753
  5. Gaston-Johansson F, Fall-Dickson JM, Bakos AB, Kennedy MJ. Fatigue, pain, and depression in pre-autotransplant breast cancer patients. Cancer Pract. 1999;7(5):240–247
  6. Glover J, Dibble SL, Dodd MJ, Miaskowski C. Mood states of oncology outpatients: does pain make a difference?. J Pain Symptom Manage. 1995;10(2):120–128
  7. Smets EM, Visser MR, Willems-Groot AF, et al. Fatigue and radiotherapy: (B) experience in patients 9 months following treatment. Br J Cancer. 1998;78(7):907–912
  8. Given CW, Given B, Azzouz F, Kozachik S, Stommel M. Predictors of pain and fatigue in the year following diagnosis among elderly cancer patients. J Pain Symptom Manage. 2001;21(6):456–466
  9. Given BA, Given C, Azzouz F, Stommel M. Physical functioning of elderly cancer patients prior to diagnosis and following initial treatment. Nurs Res. 2001;50(4):222–232
  10. Beck SL, Dudley WN, Barsevick A. Pain, sleep disturbance, and fatigue in patients with cancer: using a mediation model to test a symptom cluster. Oncol Nurs Forum. 2005;32(3):E48–E55
  11. Passik SD, Kirsh K, Theobald D, et al. Use of a depression screening tool and a fluoxetine-based algorithm to improve the recognition and treatment of depression in cancer patients: a demonstration project. J Pain Symptom Manage. 2002;24(3):318–327
  12. Passik SD. Impediments and solutions to improving the management of cancer-related fatigue. J Natl Cancer Inst Monogr. 2004;32:136
  13. Passik SD, Breitbart WS. Depression in patients with pancreatic carcinoma. Diagnostic and treatment issues. Cancer. 1996;78(3 Suppl):615–626
  14. Redeker NS, Lev EL, Ruggiero J. Insomnia, fatigue, anxiety, depression, and quality of life of cancer patients undergoing chemotherapy. Sch Inq Nurs Pract. 2000;14(4):275–290discussion 291–298
  15. Stone P, Hardy J, Broadley K, et al. Fatigue in advanced cancer: a prospective controlled cross-sectional study. Br J Cancer. 1999;79(9–10):1479–1486
  16. Stone P, Richards M, A'Hern R, Hardy J. Fatigue in patients with cancers of the breast or prostate undergoing radical radiotherapy. J Pain Symptom Manage. 2001;22(6):1007–1015
  17. Williamson GM, Schulz R. Activity restriction mediates the association between pain and depressed affect: a study of younger and older adult cancer patients. Psychol Aging. 1995;10(3):369–378
  18. Barsevick AM, Dudley WN, Beck SL. Cancer-related fatigue, depressive symptoms, and functional status: a mediation model. Nurs Res. 2006;55(5):366–372
  19. Gaston-Johansson F, Fall-Dickson JM, Nanda J, et al. The effectiveness of the comprehensive coping strategy program on clinical outcomes in breast cancer autologous bone marrow transplantation. Cancer Nurs. 2000;23(4):277–285
  20. Given CW, Given B, Rahbar M, et al. Effect of a cognitive behavioral intervention on reducing symptom severity during chemotherapy. J Clin Oncol. 2004;22(3):507–516
  21. Sarna L. Effectiveness of structured nursing assessment of symptom distress in advanced lung cancer. Oncol Nurs Forum. 1998;25(6):1041–1048
  22. Yates P, Aranda S, Hargraves M, et al. Randomized controlled trial of an educational intervention for managing fatigue in women receiving adjuvant chemotherapy for early-stage breast cancer. J Clin Oncol. 2005;23(25):6027–6036
  23. Ream E, Richardson A, Alexander-Dann C, et al. Supportive intervention for fatigue in patients undergoing chemotherapy: a randomized controlled trial. J Pain Symptom Manage. 2006;31(2):148–161
  24. Berger AM, Kuhn BR, Farr LA, et al. Behavioral therapy intervention trial to improve sleep quality and cancer-related fatigue. Psychooncology. 2009;18(6):634–646
  25. Meek PM, Nail LM, Jones LS. Internal consistency reliability and construct validity of a new measure of cancer treatment related fatigue: the general fatigue scale. Oncol Nurs Forum. 1997;24(2):334–335
  26. McNair DM, Lorr M, Droppleman LF. Profile of Mood States manual. 2nd ed.. San Diego, CA: Educational and Industrial Testing Service; 1992;
  27. McNair DM, Lorr M, Droppleman LF. Profile of Mood States (revised). San Diego, CA: Educational Industrial and Testing Service; 1992;
  28. Meek PM, Nail LM, Barsevick A, et al. Psychometric testing of fatigue instruments for use with cancer patients. Nurs Res. 2000;49(4):181–190
  29. Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193–213
  30. Carpenter JS, Andrykowski MA. Psychometric evaluation of the Pittsburgh Sleep Quality Index. J Psychosom Res. 1998;45(1 Spec No):5–13
  31. Beck S, Schwartz A, Towsley G, Dudley W, Barsevick A. Psychometric evaluation of the Pittsburgh Sleep Quality Index in cancer patients. J Pain Symptom Manage. 2004;27(2):140–148
  32. Berger AM, Wielgus KK, Young-McCaughan S, et al. Methodological challenges when using actigraphy in research. J Pain Symptom Manage. 2008;36(2):191–199
  33. Brown AC, Smolensky MH, D'Alonzo GE, Redman DP. Actigraphy: a means of assessing circadian patterns in human activity. Chronobiol Int. 1990;7(2):125–133
  34. Sadeh A, Hauri PJ, Kripke DF, Lavie P. The role of actigraphy in the evaluation of sleep disorders. Sleep. 1995;18(4):288–302
  35. Goldman SE, Stone KL, Ancoli-Israel S, et al. Poor sleep is associated with poorer physical performance and greater functional limitations in older women. Sleep. 2007;30(10):1317–1324
  36. Ancoli-Israel S, Liu L, Marler MR, et al. Fatigue, sleep, and circadian rhythms prior to chemotherapy for breast cancer. Support Care Cancer. 2006;14(3):201–209
  37. Berger AM, Farr LA, Kuhn BR, et al. Values of sleep/wake, activity/rest, circadian rhythms, and fatigue prior to adjuvant breast cancer chemotherapy. J Pain Symptom Manage. 2007;33(4):398–409
  38. Kuo H-H, Chiu M-J, Liao W-C, Hwang S-L. Quality of sleep and related factors during chemotherapy in patients with stage I/II breast cancer. J Formos Med Assoc. 2006;105(1):64–69
  39. Levin RD, Daehler MA, Grutsch JF, et al. Circadian function in patients with advanced non-small-cell lung cancer. Br J Cancer. 2005;93(11):1202–1208
  40. Cleeland CS, Gonin R, Hatfield AK, et al. Pain and its treatment in outpatients with metastatic cancer. N Engl J Med. 1994;330(9):592–596
  41. Cleeland CS. Measurement of pain by subjective report. In:  Chapman CR,  Loeser JD editor. Advances in pain research and therapy. vol. 12:New York: Raven Press; 1989;p. 391–402
  42. Cleeland CS. Research in cancer pain. What we know and what we need to know. Cancer. 1991;67(3 Suppl):823–827
  43. Nail LM, Jones LS, Greene D, Schipper DL, Jensen R. Use and perceived efficacy of self-care activities in patients receiving chemotherapy. Oncol Nurs Forum. 1991;18(5):883–887
  44. Greene D, Nail LM, Fieler VK, Dudgeon D, Jones LS. A comparison of patient-reported side effects among three chemotherapy regimens for breast cancer. Cancer Pract. 1994;2(1):57–62
  45. King KB, Nail LM, Kreamer K, Strohl RA, Johnson JE. Patients' descriptions of the experience of receiving radiation therapy. Oncol Nurs Forum. 1985;12(4):55–61
  46. Ware J, Kosinski M, Keller S. A 12-item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996;34(3):220–233
  47. Ware JE, Snow KK, Kosinski M, Gandek B. SF-36 Health Survey manual and interpretation guide. Boston, MA: The Health Institute, New England Medical Center; 1993;
  48. Ware JE, Sherbourne CD. The MOS 36-item Short-Form Health Survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992;30:473–483
  49. Thome B, Hallberg IR. Quality of life in older people with cancer—a gender perspective. Eur J Cancer Care. 2004;13(5):454–463
  50. Dajczman E, Kasymjanova G, Swinton N, et al. Does NSCLC patient-rated performance status predict survival more accurately than physician ratings? J Clin Oncol, 2007 ASCO Annual Meeting Proceedings; 25 (18S, June 20 Supplement): abstract #9022.
  51. Donovan HS, Ward S. A representational approach to patient education. J Nurs Scholarsh. 2001;33(3):211–216
  52. Brownlee S, Leventhal H, Leventhal EA. Regulation, self-regulation, and construction of the self in the maintenance of physical health. In:  Boekaerts M,  Zeidner M,  Pintrich PR editor. Handbook of self-regulation. San Diego, CA: Academic Press; 2000;p. 369–416
  53. Diefenbach MA, Leventhal H. The common-sense model of illness representation: theoretical and practical considerations. Journal of Social Distress and the Homeless. 1996;5(1):11–38
  54. Barsevick AM, Whitmer K, Walker L. In their own words: using the common sense model to analyze patient descriptions of cancer-related fatigue. Oncol Nurs Forum. 2001;28(9):1363–1369
  55. Brown J, Byers T, Thompson K, et al. Nutrition during and after cancer treatment: a guide for informed choices by cancer survivors. CA Cancer J Clin. 2001;51(3):153–187quiz 189–192
  56. Littell RC, Milliken GA, Stroup WW, Wolfinger RD. SAS System for mixed models. Cary, NC: SAS Institute, Inc.; 1996;
  57. Meyer TJ, Mark MM. Effects of psychosocial interventions with adult cancer patients: a meta-analysis of randomized experiments. Health Psychol. 1995;14(2):101–108
  58. Erickson J, Berger AM. Sleep-wake disturbances. In:  Brown C editors. A guide to oncology symptom management. Pittsburgh, PA: Oncology Nursing Society; 2010;
  59. Barsevick AM, Whitmer K, Nail LM, Beck SL, Dudley WN. Symptom cluster research: conceptual, design, measurement, and analysis issues. J Pain Symptom Manage. 2006;31(1):85–95
  60. Mooney KH, Beck SL, Friedman RH, Farzanfar R. Telephone-linked care for cancer symptom monitoring: a pilot study. Cancer Pract. 2002;10(3):147–154
  61. Brown CG, Beck SL, Peterson DE, et al. Patterns of sore mouth in outpatients with cancer receiving chemotherapy. Support Care Cancer. 2009;17(4):413–428
  62. Carpenter JS, Rawl S, Porter J, et al. Oncology outpatient and provider responses to a computerized symptom assessment system. Oncol Nurs Forum. 2008;35(4):661–669
  63. Stepanski EJ, Walker MS, Schwartzberg LS, et al. The relation of trouble sleeping, depressed mood, pain, and fatigue in patients with cancer. J Clin Sleep Med. 2009;5(2):132–136

 This study was supported by the National Institute of Nursing Research (R01NRO4573).

PII: S0885-3924(10)00326-X

doi: 10.1016/j.jpainsymman.2009.12.020

Journal of Pain and Symptom Management
Volume 40, Issue 2 , Pages 200-216 , August 2010