Journal of Pain and Symptom Management
Volume 40, Issue 5 , Pages 696-703 , November 2010

The Direct and Indirect Costs of Opioid-Induced Constipation

  • Frida Hjalte, MSc

      Affiliations

    • The Swedish Institute for Health Economics, Lund, Sweden
    • Corresponding Author InformationAddress correspondence to: Frida Hjalte, MSc, The Swedish Institute for Health Economics, P.O. Box 2127, SE-220 02 Lund, Sweden.
  • ,
  • Anna-Carin Berggren, MSc

      Affiliations

    • Mundipharma AB, Gothenburg, Sweden
  • ,
  • Henrik Bergendahl, MD

      Affiliations

    • Department of Anaesthesiology, Intensive Care and Pain Medicine, Karolinska University Hospital, Huddinge, Stockholm, Sweden
  • ,
  • Catharina Hjortsberg, PhD

      Affiliations

    • The Swedish Institute for Health Economics, Lund, Sweden

,Accepted 14 February 2010.

References 

  1. Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain. 2006;10:287–333
  2. The Swedish Pain Association (Svenska Smärtföreningen) . Report: Pain in Europe/Den svenska undersökningen The Swedish survey. Göteborg, Sweden: The Swedish Pain Association; 2003;
  3. Merskey H. Logic, truth and language in concepts of pain. Qual Life Res. 1994;3:69–76
  4. Quigley C. The role of opioids in cancer pain. BMJ. 2005;331:825–829
  5. Kalso E, Edwards JE, Moore RA, McQuay HJ. Opioids in chronic non-cancer pain: systematic review of efficacy and safety. Pain. 2004;112:372–380
  6. Benyamin R, Trescot AM, Datta S, et al. Opioid complications and side effects. Pain Physician. 2008;11(2 Suppl):S105–S120
  7. Reimer K, Hopp M, Zenz M, et al. Meeting the challenges of opioid-induced constipation in chronic pain management—a novel approach. Pharmacology. 2009;83:10–17
  8. Christopher M, Herndon C, Jackson K, Hallin P. Management of opioid-induced gastrointestinal effects: treatment. Pharmacotherapy. 2002;22:240–250
  9. Bell JT, Panchal JS, Miaskowski C, et al. The prevalence, severity, and impact of opioid-induced bowel dysfunction: results of a US and European patient survey (PROBE 1). Pain Med. 2009;10:35–42
  10. Pappagallo M. Incidence, prevalence, and management of opioid bowel dysfunction. Am J Surg. 2001;182(Suppl):11S–18S
  11. Choi Y. Opioid antagonists: a review of their role in palliative care, focusing on use in opioid-related constipation. J Pain Symptom Manage. 2002;24:71–90
  12. Annunziata K, Bell JT. Impact of opioid-induced constipation on patients and healthcare resource use. Eur J Pain. 2006;10(Suppl S1):S172
  13. Candrilli SD, Davis KL, Iyer S. Impact of constipation on opioid use patterns, health care resource utilization, and costs in cancer patients on opioid therapy. J Pain Palliat Care Pharmacother. 2009;23:231–241
  14. Cook S, Bell T, Sweeney C, Fehnel S, Hollis K. Impact on quality of life of constipation-associated GI symptoms related to opioid treatment in chronic pain patients: PAC-QOL results from the opioid survey. [abstract 883] J Pain. 2007;8:71
  15. Glia A, Lindberg G. Quality of life in patients with different types of functional constipation. Scand J Gastroenterol. 1997;32:1083–1089
  16. Panchal SJ, Müller-Schwefe P, Wurzelmann JI. Opioid-induced bowel dysfunction: prevalence, pathophysiology and burden. Int J Clin Pract. 2007;61:1181–1187
  17. Sculpher M. The role and estimation of productivity costs in economic evaluation. In:  Drummond M,  McGuire A editor. Economic evaluation in health care: Merging theory with practice. Oxford, UK: Oxford University Press; 2001;p. 94–112
  18. Drummond MF, Schulper MJ, Torrance GW, O'Brien BJ, Stoddart GL. Methods for the economic evaluation of health care programmes. Oxford, UK: Oxford University Press; 2005;
  19. University Hospital Health Care of Norrland. Pricelist 2008. 2008. Available from http://www.norrlandstingen.se/2008_bil_2_nusprislista_utg3.xls.
  20. Uppsala County Primary Care. Pricelist primary care 2008. Landstinget i Uppsala, län (County council of Uppsala), Uppsala, 2007.
  21. Stockholm-Gotland Health Care Region. Pricelist 2008. Available from http://extern.bkv.sll.se/samv.sthlm-gotland/Prislistor/2008/prislistor_2008.htm.
  22. Southern Regional Health Care Board. Prices and reimbursements for the Southern Health Care Region, 2008. Available from http://www.skane.se/upload/Webbplatser/Sodra%20regionvardsnamnden/prislista/2008/helaprislistan2008.pdf.
  23. Southeastern Health Care Region. Prices and reimbursements for the Southeastern Health Care Region 2008. 2007. Available from http://www.lio.se/upload/16047/20071218Prislista2008totversion2.pdf.
  24. Western Health Care Region. Pricelist 2008. 2008. Available from http://www.vgregion.se/upload/svn%20-%20samverkansn%C3%A4mden/Utoml%C3%A4nsprislista%202008.pdf.
  25. Örebro County Council. Pricelist for primary care 2008. 2008. Available from Örebro läns landsting (County council of Örebro), Örebro.
  26. FASS (Pharmaceuticals Specialities in Sweden). Stockholm, Sweden: the Swedish Association of the Pharmaceutical Industry AB (LIF), 2008.
  27. Statistics Sweden (SCB) . What is the info available at this website?. Available from www.scb.se2008;Accessed November 2009
  28. Ekonomifakta. Payroll tax. 2008. Available from http://www.ekonomifakta.se/sv/Fakta/Arbetsmarknad/Arbetsgivaravgift/Sociala-avgifter/.

PII: S0885-3924(10)00463-X

doi: 10.1016/j.jpainsymman.2010.02.019

Journal of Pain and Symptom Management
Volume 40, Issue 5 , Pages 696-703 , November 2010