Background and Objectives
Proper breakthrough cancer pain (BTcP) management is of pivotal importance. Although rapid-acting, oral and nasal transmucosal, fentanyl formulations (rapid-onset opioids, ROOs) are licensed for BTcP treatment, not all guidelines recommend their use. Presumably, some research gaps need to be bridged to produce solid evidence. We present a bibliometric network analysis on ROOs for BTcP treatment.
Documents were retrieved from the Web of Science (WOS) online database. The string was “rapid onset opioids” or “transmucosal fentanyl” and “breakthrough cancer pain”. Year of publication, journal metrics (impact factor and quartile), title, document type, topic, and clinical setting (in-patients, outpatients, and palliative care) were extracted. The software tool VOSviewer (version 1.6.17) was used to analyze the semantic network analyzes, bibliographic coupling, journals analysis, and research networks.
502 articles were found in WOS. A declining trend in published articles from 2014 to 2021 was observed. Approximately 50% of documents regard top quartile (Q1) journals. Most articles focused on ROOs efficacy, but abuse and misuse issues are poorly addressed. With respect to article type, we calculated 132 clinical investigations. The semantic network analysis found interconnections between the terms “breakthrough cancer pain,” “opioids,” and “cancers.” The top co-cited article was published in 2000 and addressed pain assessment. The largest number of partnerships regarded the United States, Italy, and England.
In this research area, most articles are published in top-ranked journals. Nevertheless, paramount topics should be better addressed, and the implementation of research networks is needed.
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- Breakthrough cancer pain (BTcP) management: a review of international and national guidelines.BMJ Support Palliat Care. 2018; 8: 241-249https://doi.org/10.1136/bmjspcare-2017-001467
- Italian oncological pain survey (IOPS): a multicentre Italian study of breakthrough pain performed in different settings.Clin J Pain. 2015; 31: 214-221https://doi.org/10.1097/AJP.0000000000000161
- Breakthrough cancer pain: review and calls to action to improve its management.Clin Transl Oncol. 2020; 22: 1216-1226https://doi.org/10.1007/s12094-019-02268-8
- Careful breakthrough cancer pain treatment through rapid-onset transmucosal fentanyl improves the uality of life in cancer patients: results from the BEST multicenter study.J Clin Med. 2020; 9: 1003https://doi.org/10.3390/jcm9041003
- Prevalence of pain in the departments of surgery and oncohematology of a paediatric hospital that has joined the project “Towards pain free hospital”.Clin Ter. 2016; 167: 156-160https://doi.org/10.7417/CT.2016.1948
- Management of cancer pain in adult patients: ESMO clinical practice guidelines.Ann Oncol. 2018; 29: iv166-iv191https://doi.org/10.1093/annonc/mdy152
WHO Guidelines for the Pharmacological and Radiotherapeutic Management of Cancer Pain in Adults and Adolescents. [(accessed on 26 December 2021 )]; Available online: https://apps.who.int/iris/bitstream/handle/10665/279700/9789241550390-eng.pdf?ua=1.
- Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC.Lancet Oncol. 2012; 13: e58-e68
- Multidimensional statistical technique for interpreting the spontaneous breakthrough cancer pain phenomenon. A secondary analysis from the IOPS-MS study.Cancers (Basel). 2021; 13 (Published 2021 Aug 10. doi:10.3390/cancers13164018): 4018
- A bibliometric analysis using VOSviewer of publications on COVID-19.Ann Transl Med. 2020; 8: 816https://doi.org/10.21037/atm-20-4235
- Bibliometric and visualized analysis of scientific publications on atlantoaxial spine surgery based on web of science and VOSviewer.World Neurosurg. 2020; 137 (e4. doi: 10.1016/j.wneu.2020.01.171): 435-442
- Dataset_ROOS_BTCP [Data set].Zenodo. 2022; (https://doi.org/10.5281/zenodo.5813333 Dataset)
- Semantic web technologies for the big data in life sciences.Biosci Trends. 2014; 8: 192-201https://doi.org/10.5582/bst.2014.01048
- Software survey: VOSviewer, a computer program for bibliometric mapping.Scientometrics. 2010; 84: 523-538
- Defining the clinically important difference in pain outcome measures.Pain. 2000; 88: 287-294
- Pharmacokinetics and pharmacodynamics of remifentanil. II. Model application.Anesthesiology. 1997; 86: 24-33
- Opioid-, cannabis- and alcohol-dependent women show more rapid progression to substance abuse treatment.Drug Alcohol Depend. 2004; 74: 265-272
- Clinically important changes in acute pain outcome measures: a validation study.J Pain Symptom Manage. 2003; 25: 406-411
- The management of cancer-related breakthrough pain: recommendations of a task group of the science committee of the association for palliative medicine of great britain and Ireland.Eur J Pain. 2009; 13: 331-338
- Management of cancer pain: ESMO clinical practice guidelines.Ann Oncol. 2012; 23 (vii139-54)
- Steering Committee of the European Association for Palliative Care (EAPC) Research Network. Episodic (breakthrough) pain: consensus conference of an expert working group of the European Association for Palliative Care.Cancer. 2002; 94: 832-839
- Breakthrough cancer pain: a randomized trial comparing oral transmucosal fentanyl citrate (OTFC) and morphine sulfate immediate release (MSIR).Pain. 2001; 91: 123-130
- Electroencephalographic quantitation of opioid effect: comparative pharmacodynamics of fentanyl and sufentanil.Anesthesiology. 1991; 74: 34-42
- Breakthrough pain characteristics and syndromes in patients with cancer pain. An international survey.Palliat Med. 2004; 18: 177-183
- A bibliometric analysis of publications on oxycodone from 1998 to 2017.Biomed Res Int. 2019; (2019)9096201
- Cancer pain assessment and classification.Cancers (Basel). 2019; 11: 510https://doi.org/10.3390/cancers11040510
- Understanding the chameleonic breakthrough cancer pain.Drugs. 2021; 81: 411-418https://doi.org/10.1007/s40265-021-01466-5
- Nicht-indikationsgemäßer Einsatz schnell freisetzender Fentanylzubereitungen: Stichprobenartige Fragebogenerhebung bei Kongressteilnehmern und Schmerzmedizinern [Use of rapid-onset fentanyl preparations beyond indication: a random questionnaire survey among congress participants and pain physicians].Schmerz. 2021; 35 (German): 114-123https://doi.org/10.1007/s00482-020-00503-8
- Addiction to transmucosal fentanyl: is it a cause for concern in cancer pain management?.Palliat Med. 2015; 29: 861-862https://doi.org/10.1177/0269216315593452
- Emerging opioid abuse in terminal cancer patients taking oral transmucosal fentanyl citrate for breakthrough pain.J Pain Symptom Manage. 2011; 42: e6-e8
- The triple wave epidemic: supply and demand drivers of the US opioid overdose crisis.Int J Drug Policy. 2019; 71: 183-188https://doi.org/10.1016/j.drugpo.2019.01.010
- Chronic opioid therapy in long-term cancer survivors.Clin Transl Oncol. 2017; 19: 236-250https://doi.org/10.1007/s12094-016-1529-6
- Citation-based clustering of publications using CitNetExplorer and VOSviewer.Scientometrics. 2017; 111: 1053-1070https://doi.org/10.1007/s11192-017-2300-7
Published online: February 10, 2022
Accepted: January 27, 2022
© 2022 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.