Abstract
Context
People living with HIV infection (PLWH) in the United States continue to experience
a high symptom burden despite improvements in antiretroviral therapy.
Objectives
The purpose of this study was to determine if the number and types of symptom clusters
differed based on whether symptom occurrence rates or distress ratings were used to
create the clusters.
Methods
Data from 2,000 patients with complete symptom occurrence rates and distress scores
on the 20-item HIV Symptom Index from their first ambulatory clinic visit at one of
six national HIV centers of excellence in the Center for AIDS Research Network of
Integrated Clinical Systems were used in these analyses. Exploratory factor analysis
was used to create the symptom clusters.
Results
The same four symptom clusters (i.e., gastrointestinal, psychological, pain, body
image) were identified using occurrence rates and distress ratings. For both dimensions
of the symptom experience, the psychological, pain, and body image clusters each had
the same symptoms. For the gastrointestinal cluster, four symptoms loaded on the occurrence
dimension and six symptoms loaded on the distress dimension.
Conclusion
The number and types of symptom clusters were relatively similar across the occurrence
and distress dimensions of the symptom experience. Symptom clusters in PLWH may provide
insights into the development of targeted interventions for multiple co-occurring
symptoms.
Key Words
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Article info
Publication history
Published online: February 26, 2022
Accepted:
February 18,
2022
Identification
Copyright
© 2022 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.
